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Frank Bürmann's research is focused on understanding the mechanisms that control the three-dimensional structure of chromosomes, with particular interest in bacterial genome remodelling machines. His work addresses the fundamental 'spaghetti problem' of DNA entanglements that hinder the formation of structured entities known as nucleoids and chromosomes. Bürmann investigates the role of structural maintenance of chromosomes (SMC) complexes and DNA topoisomerases in resolving these entanglements across various organisms. He is particularly interested in the function of ring-like SMC complexes and their interactions with topoisomerases to extrude large DNA loops. His research employs biochemical reconstitution, cryo-electron microscopy (cryo-EM), and advanced bacterial genetics to visualize and study the remodelling of bacterial and viral chromosomes in action. Through these efforts, he aims to achieve a comprehensive mechanistic understanding of how these processes influence chromosomal architecture throughout the tree of life.
Department of Politics and International Relations - Higher Level English requirement.