Dr. Frank Lee

Biography

Dr. Frank S. Lee is a professor in the Department of Pathology and Laboratory Medicine at the Perelman School of Medicine, University of Pennsylvania. He holds an MD and a PhD in Biological Chemistry from Harvard University. His research focuses on the molecular mechanisms of the hypoxic response, particularly the role of Hypoxia Inducible Factor (HIF) as a master regulator that upregulates genes involved in adaptation to hypoxia. Dr. Lee's work explores the regulatory mechanisms of PHD2 on HIF-α, detailing how prolyl hydroxylation impacts gene regulation during both normoxic and hypoxic conditions. His research includes collaborations studying idiopathic erythrocytosis and the genetic adaptations of high-altitude populations such as Tibetans and Andeans, providing insights into HIF pathway alterations in humans. Dr. Lee employs various methodologies, including biochemical and molecular biological techniques, as well as mouse models, to investigate these vital biological processes.

Research Interests