Dr. Franklin Pugh

Biography

Franklin Pugh is a professor at Cornell University specializing in the field of Molecular Biology and Genetics. His research focuses on uncovering fundamental molecular mechanisms of eukaryotic gene regulation, particularly through the analysis of transcription machinery and enhancer functions. The Pugh lab emphasizes the use of advanced biochemical, genetic, and computational technologies on model systems such as yeast and humans. His notable research includes the mapping of protein interactions with DNA and chromatin, contributing to a structural understanding of genetic architecture. Pugh’s methodological approaches, including CRISPR/Cas9-engineered depletion studies, aim to identify correlations between protein interactions and disease treatment outcomes, enhancing medical diagnostics. He has authored several key publications on promoter assembly and transcription initiation mechanisms. Over his career, Pugh has received numerous accolades, including serving as a Director of the Center for Eukaryotic Gene Regulation at Penn State and being elected a Fellow of the American Association for the Advancement of Science. He teaches both undergraduate and graduate courses in Molecular Biology at Cornell University.

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