Dr. Fred Winston

Biography

Fred Marshall Winston is the John Emory Andrus Professor at Harvard University, specializing in eukaryotic gene regulation, particularly transcription and its control by chromatin structure. His lab explores the mysteries of transcription regulation, aiming to uncover how aberrations in these processes can lead to diseases such as cancer. Utilizing yeast as a model system, Dr. Winston's research employs advanced genetic approaches to study gene regulation on a larger scale. His group conducts high-resolution genetic screens to investigate various aspects of gene regulation, and they implement deep-sequencing techniques to measure mRNA levels and analyze nucleosome positions and transcription factor binding. The small genome size of yeast, along with the ability to manipulate its genetic structure, facilitates rigorous in vivo analysis of complex traits and biochemical investigations of protein complexes and their post-translational modifications.

Research Interests