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Frederick M. Hughson is a Professor of Molecular Biology at Princeton University, where he also serves as the Director of Undergraduate Studies. His research primarily focuses on structural cell biology, particularly on intracellular trafficking and the protein machinery that generates the interior architecture of eukaryotic cells. His lab investigates how cargo is transported by vesicles through the cell, examining the intricate choreography set by protein complexes responsible for the creation, movement, docking, and fusion of these vesicles. Current projects involve structural and mechanistic studies of large multi-subunit protein complexes that orchestrate these processes. Additionally, Hughson's work extends into quorum sensing in bacteria, exploring the communication strategies of single-celled organisms and the molecular signals they produce. He utilizes biochemical and biophysical methods to study the enzymes and receptors involved in these signaling pathways, aiming to identify antagonists that can inhibit undesirable bacterial communication.
GRE scores are not accepted. Ph.D. is the primary degree; students are not required to hold an M.S.E. prior to admission.