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The Gu Lab at Harvard Medical School focuses on understanding the cellular physiological mechanisms underlying the unique neurovascular interactions within the blood-brain barrier and neurovascular coupling. The laboratory aims to explore the delicate interface between the nervous and vascular systems, investigating how brain vascularization influences brain functions. Neurons are highly sensitive to their extracellular chemical environment, and the blood-brain barrier provides a safe homeostatic environment for the brain. Given that the brain accounts for a small percentage of body weight yet consumes a significant portion of the body’s energy, understanding how local blood flow is regulated in response to neural activity is crucial. The lab employs various experimental approaches, including mouse genetics, transcriptional profiling, and advanced imaging techniques, to examine the molecular and cellular mechanisms that govern the exchange of molecules between neurons and the blood. This research is pivotal for developing new therapeutic strategies to address neurological conditions and improve drug delivery across the blood-brain barrier.
Administered by the Division of Medical Sciences (DMS). GRE is not required and will not be considered for BBS, Immunology, and Neuroscience.