Dr. Gabriel Rocklin

Biography

Gabriel J. Rocklin is an Assistant Professor in the Department of Pharmacology at Northwestern University's Feinberg School of Medicine. His research focuses on developing high-throughput methods for protein biophysics and protein design, particularly in the realm of protein therapeutics. He addresses critical questions regarding protein folding stability, conformational dynamics, and the resistance of proteins to aggregation under various stresses. By leveraging computational modeling, he seeks to quantitatively predict the relationship between protein sequences (genotype) and their resulting structures and functions (phenotypes). His work combines de novo computational protein design with high-throughput display methods, mass spectrometry proteomics, and next-generation sequencing to test thousands of proteins in parallel. This integrated approach aims to refine the design, testing, and analysis cycles necessary for advancing protein biophysics and developing improved therapeutic proteins. Rocklin's contributions are recognized by his membership in the Biophysical Society and Rosetta Commons, and he has received the prestigious NIH Director's New Innovator Award for his unconventional research endeavors in biomedical sciences.

Research Interests

Experience