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Dr. Gary Lopaschuk is a leading researcher in the field of energy metabolism and its regulation in the heart. He holds a PhD in Pharmacology and Toxicology from the University of British Columbia. As an Adjunct Professor at the University of Alberta and an AHFMR Scientist, Dr. Lopaschuk's lab focuses on understanding how energy substrates are utilized by the heart in both physiological and pathological conditions. His research reveals that under various forms of heart disease, fatty acids become the predominant fuel source, which can be detrimental to cardiac function. Dr. Lopaschuk advocates for pharmacological strategies that can inhibit fatty acid utilization while enhancing carbohydrate metabolism to improve heart function, particularly in diabetic patients. His studies aim to optimize cardiac energy utilization and to develop therapeutic approaches that protect the heart, especially in clinical settings like cardiac surgery. He has published numerous papers highlighting the role of fatty acid oxidation and metabolic modulation in heart disease.
Department: Mechanical Engineering and Engineering Management