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Gary B. Ruvkun is a Professor at Harvard University in the Department of Genetics. His research focuses on the roles of microRNAs and small RNAs in various biological processes, including longevity, immune surveillance, and gene regulation. His significant contributions include the discovery of the lin-4 microRNA in collaboration with Victor Ambros in 1992, which regulates translation of the target gene lin-14. His lab went on to identify the let-7 microRNA in 2000, which has been shown to regulate diverse biological functions across species. The Ruvkun lab's pioneering work has led to substantial advancements in the understanding of microRNA biology, particularly its implications in human health, including heart disease and the regulation of cellular processes. The lab employs a variety of genomic techniques, including RNAi libraries, to explore genetic pathways related to aging and metabolism. Ruvkun's approach emphasizes the training of students and postdocs to develop their own projects, fostering intellectual flexibility and confidence within the scientific inquiry framework.
Harvard University • Boston, MA
Leading research on microRNAs and their roles in gene regulation and biological processes.
Administered by the Harvard Kenneth C. Griffin Graduate School of Arts and Sciences (GSAS).