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Gary Shaw is a Professor in the Department of Biochemistry at Western University. He completed his PhD at McMaster University and has served as a Postdoctoral Scholar at the University of Alberta. His research focuses on the mechanisms underlying the ubiquitin-mediated degradation pathway, specifically related to the removal of unwanted proteins within cells. A key area of investigation is Parkinson's Disease, where Shaw studies the functionality of proteins like parkin and E2 conjugating E3 ligase enzymes. Utilizing biophysical techniques such as NMR, the research aims to enhance understanding of the structure and function of these proteins, investigating what goes wrong in cases of mutations associated with Parkinson's Disease. Another significant component of his research is membrane repair and trafficking, particularly through the study of calcium-binding proteins, including the S100 family of calcium sensors, with a specific focus on S100A10. Shaw's ongoing work includes designing small molecules that can influence the interactions and functions of these binding partners, contributing valuable insights to the field of biochemistry.
Streams include Archaeology and Bioarchaeology, and Sociocultural Anthropology.