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Geoffrey Greene is the Virginia D. K. Ludwig Professor at the University of Chicago, where he conducts research in the field of cancer biology. His work primarily focuses on the mechanisms of hormone receptor action in cancer, particularly breast and prostate cancers. Greene has significant expertise in developing and characterizing novel compounds that selectively target estrogen receptors and other steroid hormone receptors. His laboratory has made substantial contributions to the understanding of how ligand binding induces conformational changes in hormone receptors, influencing their interaction with coregulators and determining their transcriptional activity. Greene’s research includes structural studies, where he has elucidated the crystal structures of several hormone receptors, enhancing the knowledge of drug-receptor interactions. He is also involved in investigating the role of nuclear receptor coactivators in cancer metastasis and treatment resistance. Across his career, he has received numerous awards for his scientific contributions, including being named a Fellow of the American Association for the Advancement of Science and receiving the Susan G. Komen Cure Brinker Award for Scientific Distinction. Greene continues to impact the field through his innovative research and mentorship of emerging scientists.
Department of Philosophy