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George M. Shaw, M.D., Ph.D. is a Professor of Medicine specializing in Hematology-Oncology at the Perelman School of Medicine, University of Pennsylvania. He has a longstanding interest in molecular biology and the immunopathogenesis of human diseases such as HIV-1 and hepatitis C virus (HCV). His notable research includes pioneering work on HIV-1 molecular clones and the quasispecies nature of HIV-1 in vivo. Shaw's laboratory has significantly contributed to understanding the persistent nature of viral replication and virus persistence in the face of evolving immune responses. He has also explored the molecular identification and characterization of transmitted/founder HIV-1 genomes. His current projects focus on HIV-1 transmission and pathogenesis, the molecular mechanisms of broadly neutralizing antibodies (bNAbs), and HCV transmission. Shaw has developed innovative strategies for constructing simian-human immunodeficiency virus chimeras to aid in HIV-1 vaccine development, emphasizing the practical applications of bNAb design and assessment. He is involved in both basic and translational research aimed at creating effective vaccine strategies against HIV-1 and HCV infection.
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