Dr. Georgina Benn

Biography

Georgina Benn's research focuses on understanding the organization and mechanics of the bacterial outer membrane, particularly in Gram-negative bacteria like E. coli. This membrane presents a formidable barrier to antibiotic penetration, making these organisms a priority in the quest for new antimicrobials. The complexity of the outer membrane, made up of a mixture of lipoproteins, beta-barrel proteins, and unique lipids, complicates drug design efforts aimed at circumventing this barrier. Benn's work has demonstrated that the outer membrane is denser than previously assumed, with a network of immobile lattice proteins linked by a thin layer of lipids. This organization plays a crucial role in maintaining the mechanical properties of the cell and facilitating cell division. Her interdisciplinary research employs advanced techniques such as atomic force microscopy and super-resolution microscopy to investigate live bacteria at the nanoscale and larger organizational scales. The overarching goal of her work is to gain insights into the outer membrane’s structural properties and its role in the physiology of bacteria.

Research Interests