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Gerhard Wagner's research focuses on the structures of proteins and protein complexes and their functional roles using NMR spectroscopy, biophysical techniques, and computational tools. He is particularly interested in the mechanisms behind cellular processes, including the interactions of cap-binding proteins such as eIF4E and scaffold proteins like eIF4G, as well as regulatory 4E-BPs. His work includes the identification of small-molecule inhibitors that target the eIF4E/eIF4G interaction and have shown anti-tumor activity. Wagner also explores the roles of eukaryotic initiation factors in cellular transformation and apoptosis, examining protein-protein interactions involving the Bcl-2 family and the mitochondrial membrane protein VDAC. His lab has developed methods for working with membrane proteins, including the use of covalently circularized phospholipid nanodiscs to create stable preparations for membrane protein studies.
Harvard University • Boston, MA
Professor focused on structural biology and molecular pharmacology.
Administered by the Harvard Kenneth C. Griffin Graduate School of Arts and Sciences (GSAS).