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Gideon Dreyfuss is an Isaac Norris Professor in the Department of Biochemistry at the Perelman School of Medicine, University of Pennsylvania. He specializes in RNA-binding proteins and has conducted significant research into the Survival Motor Neurons (SMN) complex and its role in Spinal Muscular Atrophy (SMA), a common neurodegenerative disease. His work focuses on understanding the functional forms of RNAs and the formation of ribonucleoprotein (RNP) complexes that include RNA-binding proteins. Dreyfuss has identified key proteins that interact with RNAs and characterized their roles in mRNA splicing and transport, thus contributing to the understanding of post-transcriptional gene expression. His current research explores the dynamics of the SMN complex and its implications in various genetic diseases, particularly SMA. He employs high-throughput screening methods to discover potential therapeutics aimed at increasing the levels of functional SMN protein in affected cells.
Wharton Doctoral programs cover fields like Finance, Marketing, Management, and Operations, Information and Decisions.