Dr. Gloria Lopez Castejon

Biography

Gloria Lopez Castejon holds a degree in Biochemistry from the University of Murcia, Spain, and obtained her PhD in Immunology in 2007, investigating the mechanisms of Interleukin-1β release in teleost fish. She moved to Manchester to focus her research on the study of purinergic receptor P2X7 activation and the inflammasome complex in macrophages. In 2013, she joined the Manchester Collaborative Centre for Inflammation Research (MCCIR) as a postdoctoral fellow, further researching the mechanisms of inflammasome activation. In 2015, she was awarded the Wellcome Trust Sir Henry Dale fellowship to investigate new roles of deubiquitination in the inflammatory response. Her research interests lie in the molecular mechanisms of inflammation in response to infection and injury, exploring how immune cells sense danger and release pro-inflammatory molecules. Her research also investigates the regulation of the inflammasome, which plays a crucial role in releasing potent pro-inflammatory cytokines like interleukin-1β and interleukin-18. Overall, her work aims to understand and control chronic inflammation, contributing to the design of new specific drugs to block the inflammatory process, leading to the development of effective novel anti-inflammatory therapies.

Research Interests