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Professor Grant Brown focuses on DNA replication, DNA damage repair, genome instability, and their implications in cancer and aging. He received his Ph.D. in Molecular Biology from UCLA, where he studied DNA replication in Dan S. Ray’s lab. Following his doctorate, he completed a postdoctoral fellowship at Johns Hopkins University School of Medicine, working with Tom Kelly on S phase regulation in fission yeast. His research aims to understand how cells maintain genome stability amidst the daily challenges posed by internal sources of DNA lesions, such as oxidative damage and replication errors. Brown's work highlights the significance of DNA damage in genetic rearrangements, which are key contributors to cancer and aging, and he is exploring the therapeutic potential of DNA damaging agents in cancer treatment. He utilizes high-throughput screening methods for the global identification of genes and pathways involved in the DNA damage response and conducts detailed analyses to comprehend how cells react to DNA replication stress. His studies often employ budding yeast and mammalian cells as model systems to unravel the genetics of cell cycle regulation and genome stability.
University of Toronto • Toronto, Ontario, Canada
Teaching and conducting research in DNA replication and damage repair.
University of Toronto • Toronto, Ontario, Canada
Conducted research and taught courses related to biochemistry.
Johns Hopkins University School of Medicine • Baltimore, Maryland, USA
Studied regulation of S phase in fission yeast.
Department of Sociology