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Greg Barton's training and expertise span areas of immunology, microbiology, cell biology, and mouse genetics. His research lab focuses on microbial detection and the innate immune system, exploring the links between innate and adaptive immunity. He developed new transgenic mouse strains in graduate student Alexander Rudensky’s lab that addressed the importance of MHC-bound self-peptides in T cell selection. His postdoctoral training under Ruslan Medzhitov emphasized innate immunity, with notable studies demonstrating Toll-like receptors’ (TLRs) roles in controlling the induction of adaptive immunity. Notably, Barton began studying TLR specificity for nucleic acids to avoid responses to self DNA and RNA, and his group has characterized key aspects of TLR trafficking and its profound impacts on receptor function. His ongoing research continues to explore self versus non-self discrimination mechanisms, host-microbe interactions, and how innate immunity regulates adaptive responses. His lab is recognized for discoveries in the regulatory mechanisms of TLRs and their roles in immune functionality.
University of California, Berkeley • Berkeley, CA
Conducting research and teaching courses in the Department of Molecular and Cell Biology.
The Mathematics Subject GRE is required for the Fall 2026 admissions cycle. General GRE is optional.