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Guia Cerretelli is a Post-Doctoral Visiting Scientist at the University of Edinburgh, working at the Cancer Research UK Scotland Centre within the Institute of Genetics and Cancer. Her current research focuses on intestinal tumour modeling and the investigation of DNA damage involved in ethanol-induced colorectal carcinogenesis. This research aims to elucidate the mechanisms by which ethanol and its metabolite acetaldehyde contribute to the formation of colorectal cancers, particularly in the context of defective DNA mismatch repair (dMMR). Approximately 13% of sporadic colorectal cancers are characterized by dMMR, often driven by acquired MLH1 promoter methylation, while around 3% are due to inherited mutations associated with Lynch Syndrome. In her project, she tests the hypothesis that the MMR pathway is involved in the repair of DNA base adducts induced by ethanol and acetaldehyde, suggesting that ethanol may accelerate tumour formation through unrepaired DNA damage.
Cancer Research UK Scotland Centre • Edinburgh, Scotland
Engaged in research focusing on the mechanisms underlying ethanol-induced colorectal carcinogenesis and the role of DNA mismatch repair in tumor formation.
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