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Guilherme P.F. Nader is an Assistant Professor in the Department of Pathology and Laboratory Medicine at the Perelman School of Medicine, University of Pennsylvania. He received his B.S. and M.S. from the University of São Paulo, Ribeirão Preto, Brazil, and earned his Ph.D. from Columbia University in 2015. Dr. Nader’s research program focuses on elucidating how cell nucleus affects cell function and fate in response to the degrees of nuclear deformation observed during cell migration in complex microenvironments and tissue crowding. His primary research interests include nuclear mechanosensing, DNA damage, cell migration, and the role of mechanical forces in cancer development and progression. Nader's work involves investigating mechanisms regulating cellular motility and the transcriptional programs associated with confined cancer cells, particularly those with fragile mutant nuclei that are responsive to mechanical stress. His lab provides insights into the impact of the tumor microenvironment on nuclear behavior and cancer cell invasion.
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