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Guilherme P.F. Nader is an Assistant Professor in the Department of Pathology and Laboratory Medicine at the Perelman School of Medicine at the University of Pennsylvania. His research program focuses on elucidating how the cell nucleus affects cellular function and fate, particularly in response to the nuclear deformation observed during cell migration in complex microenvironments. He investigates nuclear mechanosensing, DNA damage, cell migration, and the effects of microfabrication on cellular behavior. His work includes a range of projects from understanding the role of TREX1 nuclease in regulating nucleic acid damage due to mechanical stress, to exploring transcriptional programs in confined cancer cells with fragile nuclei. His recent findings highlight how nuclear stress, caused by dense microenvironments, can lead to DNA damage and influence tumor cell invasiveness. Nader utilizes innovative organ-on-a-chip devices to study these phenomena under conditions that mimic live tissues, providing insights that could lead to new therapeutic strategies in oncology and regenerative medicine. For further information, please visit his lab website.
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