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Guo Dong Zhou is a Research Assistant Professor at the Center for Translational Cancer Research, focusing on the mechanistic role of cytochrome P450 (CYP) enzymes in preventing polycyclic aromatic hydrocarbon (PAH)-mediated pulmonary carcinogenesis through omega-3 fatty acids. His research emphasizes the importance of CYP enzymes in drug metabolism and bioactivation, particularly how they metabolize omega-3 fatty acids into epoxy metabolites that inhibit angiogenesis, tumor growth, and metastasis. Zhou has demonstrated that PAHs are human carcinogens leading to DNA damage and mutations, contributing to cancer development. He reported a significant positive correlation between PAH-DNA adduct levels and tumor incidence in laboratory animal studies. Zhou's findings highlight that omega-3 fatty acids, specifically eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA), inhibit key enzymes associated with tumor progression. His central hypothesis suggests that omega-3 fatty acids and their metabolites could attenuate pulmonary carcinogenesis, potentially through regulatory mechanisms involving tumor suppressor genes. His proposed studies aim to uncover novel dietary interventions for preventing PAH-induced cancers in humans.
Department: Department of Communication and Journalism. Ph.D. program only currently admitting. GRE is test-optional.