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The Rosania lab studies the microscopic transport properties of small drug-like molecules within cells. The overarching hypothesis is that a drug's microscopic distribution within organelles is crucial for its macroscopic distribution in organs, which ultimately determines its efficacy and toxicity. Utilizing microscopic imaging instruments, the lab captures the local distribution dynamics of small molecules in cells and applies innovative computational tools and statistical strategies, combining cheminformatics and machine vision to relate the chemical structure of small molecules to their subcellular distribution. They develop biochemical analysis methods to study the microdistribution and cellular pharmacokinetics of small drug-like molecules, seeking to build mathematical models that simulate drug transport and distribution within single cells and higher-order cellular organizations, based on fundamental biophysical principles governing molecular transport phenomena. Their vision is a future where drugs are designed and optimized based on their site and mechanism of action.
UM College of Pharmacy • Ann Arbor, MI
Teaching and conducting research in the field of Pharmaceutical Sciences, focusing on drug transport and distribution.
Department of Electrical Engineering and Computer Science