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Guy Groblewski is a Professor in the Department of Nutritional Sciences specializing in intracellular signal transduction and membrane/protein trafficking in gastrointestinal epithelial cells. His research primarily focuses on the exocrine pancreas, particularly the synthesis, storage, and secretion of digestive enzymes necessary for the breakdown and assimilation of the diet. The main intracellular messenger mediating exocytosis is the rise in concentration of cellular Ca2+. In pathophysiological conditions, aberrant elevations of Ca2+ inhibit exocytosis and promote lysosome-mediated activation of digestive enzymes, marking the earliest stages of pancreatitis. Despite significant advances in understanding the mechanisms mediating Ca2+ mobilization, comparatively little is known about the regulatory proteins responding to elevated Ca2+ levels in the cytoplasm. His laboratory aims to elucidate the precise downstream molecular events that occur as a consequence of acutely elevated Ca2+ in secretory epithelia. Understanding Ca2+-signaling pathways in the pancreas is essential for comprehending the pathophysiology of acute pancreatitis and pancreatic cancer.
Department: Department of Computer Sciences