Dr. Hai Zhang

Biography

Hai Feng Zhang is an Associate Research Scientist at Yale School of Medicine, focusing on the mechanisms underlying heart vascular diseases caused by inflammation. His research underscores the role of excessive and chronic inflammatory responses, specifically involving tumor necrosis factor (TNF), which increases the production of reactive oxygen species (ROS), a common pathogenic mechanism involved in atherosclerosis. His work examines how vascular endothelial cells (EC) limit inflammatory processes associated with atherosclerosis, particularly looking at how inflammation and ROS induce EC dysfunction, disturbing normal homeostasis and survival. Zhang's experiments are designed to dissect the signal pathways involved in inflammatory responses, and he has identified AIP1 as a critical mediator in TNF signaling pathways, illustrating its interactions with various signaling proteins. Additionally, he is investigating AIP1's functions in tumor suppression, contributing to a broader understanding of vascular biology, inflammation, and diabetes.

Research Interests

Experience