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Hannele Ruohola-Baker is a Professor of Biochemistry at the University of Washington and Associate Director at the Institute for Stem Cell and Regenerative Medicine (ISCRM). Her research focuses on understanding the molecular mechanisms that control stem cell self-renewal and regeneration capacity under normal and pathological conditions. She has identified metabolic differences between pluripotent stem cells and examines how certain metabolites regulate epigenetic states. Her laboratory addresses critical questions including the metabolic determinants of stem cell regeneration, stem cell aging, and employing stem cells to dissect mechanisms underlying various disease states. Current projects involve studying the etiology of long chain fatty acid-induced Sudden Infant Death Syndrome (SIDS), heart defects, and the genetic disorder Amelogenesis Imperfecta (AI), specifically in relation to the role of stem cells in the development of ameloblasts, which are essential for enamel deposition. Ruohola-Baker has significant expertise in Notch signaling and its requirement in polarizing epithelial cells, with a focus on Drosophila models for understanding these processes.
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