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Hannele Ruohola-Baker is an Adjunct Professor at the University of Washington's Department of Biology. Her laboratory focuses on understanding the dynamics of differentiation in stem cells, employing a variety of multi-disciplinary approaches including in vivo, ex vivo, and in vitro models that range from Drosophila to mouse, human embryonic stem cells (hESC), and induced pluripotent stem cells (iPSC). In recent years, her research has highlighted the critical roles of microRNAs and the hypoxia-inducible factor (HIF) pathway in regulating both adult and embryonic stem cells. Notably, her laboratory conducted an unbiased Drosophila interaction screen that discovered the therapeutic effects of the sphingosine-1-phosphate (S1P) pathway on muscular dystrophies. Increased levels of S1P have demonstrated beneficial effects on adult stem cell-based muscle regeneration in the mdx mouse model of Duchenne Muscular Dystrophy (DMD). The basic studies conducted in her lab are directed towards long-term goals of understanding stem cell regulation in development and disease.
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