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Hanno Hock is a clinician-scientist affiliated with the Harvard Stem Cell Institute and Massachusetts General Hospital. His research focuses on transcriptional regulation during normal blood cell development and leukemia. His studies explore how hematopoietic stem cells (HSCs), which give rise to blood cells, undergo significant transcriptional changes as they mature into specific blood lineages. The research investigates the role of transcription factors in ensuring that genes specific to immature cells remain repressed until differentiation occurs, and how these factors may perform opposing functions in different lineages. By examining key transcription factors and their impact on differentiation, Hock aims to understand the transcriptional programs that are disrupted by abnormal factors, leading to leukemia.
Massachusetts General Hospital • Cambridge, MA
Conducts research and clinical practice focusing on hematopoietic development and leukemia.