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Hao Wu is an Associate Professor in the Department of Genetics at the Perelman School of Medicine, University of Pennsylvania. With a Ph.D. in Epigenetic Regulation of Neural Stem Cell Differentiation from the University of California, Los Angeles, his research focuses on epigenetic mechanisms that govern gene expression and cell-type specification in multicellular organisms. The Wu lab combines various experimental methodologies such as biochemical, molecular, genetic, and genomic assays with bioinformatics to explore interactions between the epigenome and environmental signals. Wu’s team aims to quantitatively analyze how these interactions impact human pathologies and developmental processes. His lab's long-term objective is to develop innovative epigenome editing tools and high-precision single-cell epigenomic profiling methods to enhance understanding of gene regulation in mammalian development. Wu has contributed significantly to the field through his publications that explore the dynamics of DNA and histone modifications in relation to cellular responses to environmental and metabolic conditions.
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