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Harikesh S. Wong studies how cells assemble and communicate to control immune responses in tissues. His research focuses on how the immune system mounts destructive responses to protect the host from threats, such as pathogens and tumors. However, a trade-off emerges where these immune responses can cause tissue damage and compromise the host's function. Wong's lab investigates how cells communicate with their surrounding tissue environment to accurately control the magnitude of immune responses in both time and space. To achieve this, his team employs a combination of immunological tools and interdisciplinary methods, including high-resolution fluorescence microscopy, computational approaches, and gene manipulations. Their ultimate goal is to understand the subtle shifts in control that lead to widely divergent outcomes in hosts, which can include successful elimination of threats, tolerance, autoimmunity, chronic infection, and cancer.