Dr. Harinder Singh

Biography

Harinder Singh is a Professor and Director of the Center for Systems Immunology at the University of Pittsburgh. He has a Ph.D. in Molecular Biology from Northwestern University, completed in 1984. His research focuses on experimental computational analyses of gene regulatory networks that control immune effector memory cell states. Singh has long-standing interests in the discovery and analysis of transcription factors (TFs) and their roles in the regulation of development and function of immune cells. Notably, as an HHMI Investigator at the University of Chicago, his lab identified the Ets family member PU.1 as essential for the development of multiple myeloid and lymphoid lineages. His work has illuminated the molecular functions of PU.1 in the development of B cells and macrophages and has involved collaborations leading to the cloning of IRF4, a partner of PU.1. Singh’s research also includes investigations into how IRF4 and related proteins regulate immune responses. He has established the Center for Systems Immunology to foster interdisciplinary research collaborations that enhance understanding of high-dimensional datasets through advanced analytic pipelines and machine learning.

Research Interests

Experience