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Harry Ischiropoulos is a Research Professor in the Pediatrics department at the University of Pennsylvania's Perelman School of Medicine. He focuses on biological chemistry and the molecular mechanisms of nitric oxide signaling. His work studies how nitric oxide acts as a free radical to mediate blood flow and physiological responses in major organ systems. Currently, he employs mass spectrometry-based proteomics combined with structure-function analysis to explore the biochemical and biophysical specificity of nitric oxide-mediated post-translational modifications, such as cysteine S-nitrosation and tyrosine nitration. His research includes generating inventories of mouse brain proteomes, phosphoproteomes, and S-nitrosoproteomes, which are used to create 3D functional landscapes of the mouse brain's extracellular space to identify signaling pathways that influence neuron physiology and neurodegeneration.
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