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Harvey Rubin is a Professor of Medicine at the Perelman School of Medicine, University of Pennsylvania, and an Attending Physician specializing in Infectious Diseases. He is also the Director of the Institute for Strategic Threat Analysis and Response (ISTAR). His research focuses on elucidating genetic and metabolic regulatory networks allowing tuberculosis to persist in human hosts, and the molecular basis of serine protease inhibition. Rubin's work on tuberculosis investigates its pathogenesis and dormancy, exploring how oxygen limitation and nutrient starvation contribute to the dormant state of Mycobacterium tuberculosis. He has identified key genetic systems involved in this dormancy, including ribonucleotide reductase systems and stringent response systems. Additionally, he is pioneering research in biomolecular computation and is collaborating with the School of Engineering to model complex biological behaviors using hybrid systems. His studies are supported by the NIH and NSF, aiming to understand the roles of serine proteases and their inhibitors in various biological processes.
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