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Helen obtained her BSc in Biochemistry from the University of Bath in 1998 and moved to the University of St Andrews for her PhD, where she investigated the structural basis of protein hyperthermostability. In 2001, she joined Brenda Schulman's newly-established lab at St Jude's Children's Research Hospital in Memphis, Tennessee as a postdoctoral researcher, developing an interest in the mechanisms of ubiquitination and solving the structure of E1 Nedd8. In 2005, Helen moved to the Lincoln's Inn Fields Laboratories at the Cancer Research UK’s London Research Institute (now known as the Francis Crick Institute) to establish her own research group. During her tenure, she transitioned to the MRC-Phosphorylation Ubiquitylation Unit at the University of Dundee, and in 2017 relocated her lab to the University of Glasgow as a Professor of Structural Biology. Helen was a member of the EMBO Young Investigator Programme from 2011 to 2014, received the Colworth Medal from the Biochemical Society in 2015, and in 2016 received an ERC Consolidator Award.