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Heng-Chi Lee is an Associate Professor in the Biological Sciences Division at the University of Chicago. His research interests encompass the study of C. elegans and the intricate roles of small non-coding RNAs in regulating gene expression and genome integrity. His pioneering work investigates the mechanisms behind piRNA-mediated gene silencing and the essential functions these small RNAs play in cellular defense against foreign nucleic acids and transposons. Lee's recent studies have shed light on how piRNAs establish 'non-self memory' within the genome and how they can silence targets across generations. With a focus on genetic and biochemical approaches, his lab aims to unravel key principles governing small RNA-based genome defense mechanisms. Significant findings from his research have implications for understanding molecular pathogenesis connected to infertility. Lee has contributed to numerous publications within the field, including explorations into the dynamics of germ granules and their role in piRNA surveillance, highlighting the importance of ribonuclease actions during transcriptome regulation. His work serves as a critical resource for advancing knowledge in genetics, epigenetics, and molecular biology.
Department of Philosophy