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Hening Lin is a researcher focusing on how enzymes post-translationally modify proteins and the physiological functions of these enzymes. His work examines nicotinamide adenine dinucleotide-consuming enzymes and their roles in biological processes. Lin leads a team that combines organic chemistry, biochemistry, and cell biology alongside mouse genetics to discover new enzymatic activities. His research specifically emphasizes the regulation of enzymes, which reveals key physiological functions. The insights gained from this work enable the Lin team to develop small molecule inhibitors as potential therapeutics for treating human diseases. Through rigorous investigation and innovative approaches, Lin strives to understand the complexities of enzyme function and regulation in health and disease.