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Henry Markram started a dual scientific medical career at the University of Cape Town, South Africa. His scientific work in the 1980s revealed polymodal receptive fields in pontomedullary reticular formation neurons. In 1988, he moved to Israel to obtain his PhD at the Weizmann Institute, discovering a link between acetylcholine and memory mechanisms. His research showed how acetylcholine modulates NMDA receptors, enabling synaptic plasticity. Markram has had significant postdoctoral experiences at NIH and the Max Planck Institute, exploring ion channels and synaptic vesicles. He discovered the phenomenon known as Spike Timing Dependent Plasticity (STDP). He continued his research as a tenured professor at EPFL, founding the Brain Mind Institute and initiating the Blue Brain Project. His lab focuses on computational neuroscience, exploring the neocortex, synaptic dynamics, and the implications of hyper-connectivity in autism through the theory of Intense World Syndrome, proposed with Kamila Markram. Markram's work aims to build detailed models of mammalian brains to enhance understanding of neural systems and address neurological diseases.
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