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Emeritus Professor Herb Arst's group focuses on basic research in microbial genetics, particularly in the areas of fungal gene regulation. His current research interests center around the regulation of gene expression in response to ambient pH and calcium signaling homeostasis. The pH regulatory system manages the expression of genes involved in the export of metabolites such as toxins and antibiotics, as well as the functioning of extracellular enzymes crucial for nutrient uptake. This research is vital for understanding fungal infections in plants and animals. Additionally, Professor Arst's calcium project was initiated through the identification of novel mutational combinations leading to strains that require high levels of calcium for growth, which serves as an activity indicator of calcium status. Previous work suggests that disruptions in calcium signaling and homeostasis could hinder fungal virulence, shedding light on mechanisms that resemble the regulatory systems in higher eukaryotes. His research has been published in various scientific journals, including Trends in Genetics.
Specialisms available in Materials for the Energy Transition or Theory and Simulation of Materials.