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Dr. Herbert Cohen is an Associate Professor at Boston University's Chobanian & Avedisian School of Medicine specializing in Nephrology. His research primarily focuses on the molecular basis of renal cancer, renal cystic disease, and renal development, demonstrating a particular expertise in gene expression mechanisms, signal transduction, and protein-protein interactions. His laboratory has identified a member of a new protein family known as Jade family proteins, which are involved in the interaction with the von Hippel-Lindau tumor suppressor protein pVHL, a key component of the cellular oxygen-sensing system. This pathway is critically important to renal cancer development, given that VHL is a major renal cancer gene in adults. Cohen's work has identified Jade-1 as a growth-suppressive plant homeodomain transcription factor protein that plays a crucial role in regulating renal cyst formation and is related to the major gene for autosomal dominant polycystic kidney disease (ADPKD). Additionally, Jade-1 is an important ubiquitin ligase for the oncoprotein beta-catenin, which is vital in renal cancer and development. Through advanced molecular biology techniques, Dr. Cohen's research contributes to understanding the broader implications of these proteins in kidney pathology.
Department of Law offers JD, LLM, and Master's in Study of Tax Law.