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Hilliard Foster Seigler is a Professor Emeritus in the Duke Department of Surgery, focusing on tumor immunobiology with a special interest in human melanoma. His laboratory currently focuses on cellular and humoral responses to melanoma tumor cell vaccines. Seigler completed Duke University's gene therapy program, utilizing autologous melanoma cells transduced with the human gamma interferon gene. His studies have shown that patients made significant measurable responses to immunization with gene-modified tumor cells, with 100 patients being immunized using autologous dendritic cells pulsed with autologous tumor lysate and specific melanoma tumor peptides. The cell-mediated immune response to the vaccines was addressed serially, and he has been evaluating HLA identical donor stem cells in an effort to produce graft versus tumor responses in patients with metastatic melanoma.
Duke Department of Surgery • Durham, NC
Professor Emeritus in the Department of Surgery at Duke University.
Department of Immunology •
Previously held a position as a Professor in the Department of Immunology.
Department of Microbiology and Immunology •
Held a position as Professor of Immunology in the Department of Microbiology and Immunology.
Department of Biomedical Engineering (MS program)