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Holger Wille is a Professor in the Department of Biochemistry at the University of Alberta. He holds a Ph.D. from Universität Hamburg in Germany. As the Director of the Centre for Prions and Protein Folding Diseases, Wille's research primarily focuses on the structure of amyloids associated with disease-related misfolded proteins. He has a particular interest in the structure-function relationship of the infectious prion protein (PrPSc) that underlies its infectious nature. Recent studies highlight the involvement of prion-like mechanisms in neurodegenerative diseases such as Alzheimer's, Parkinson's, and Lou Gehrig's disease. Wille employs advanced experimental approaches including electron microscopy, X-ray fiber diffraction, and various biochemical methods to unravel these complex biological phenomena. His work contributes significantly to understanding the molecular underpinnings of classical prion diseases and exploring novel therapeutic avenues. Wille has published extensively, with notable publications addressing topics such as the protective effects of fibronectin in prion infection and structural studies of prion protein conversions.
University of Alberta • Edmonton, AB, Canada
Professor in the Department of Biochemistry and Director of the Centre for Prions and Protein Folding Diseases.
Department: Mechanical Engineering and Engineering Management