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Homme Wytzes Hellinga is a James B. Duke Distinguished Professor of Biochemistry at Duke University. His research employs a combined theoretical and experimental approach to address problems in structural biophysics, particularly utilizing computer simulations to understand protein folding, stability, and activity, as well as the specificity of protein-ligand interactions. Hellinga's innovative design methods allow for rational modifications of protein structure and function, enabling targeted experimental tests. The empirical improvement techniques include genetic selection on a range of designed proteins. He has developed various computer algorithms to engineer biologically active receptors, sensors, and enzymes, leading to the creation of novel biosensors for clinical and environmental applications. Furthermore, his work extends to synthetic biology, where he devises signal transduction pathways and genetic circuits to allow bacteria to report environmental changes. Hellinga’s efforts are instrumental in advancing bionanotechnology through the design of chemically controlled molecular motors and novel enzymes.
Department of Biomedical Engineering (MS program)