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Dr. Hui-Kuan Lin is an Endowed Chair Professor in the Department of Pathology at Duke University. With a distinguished career focused on the study of oncogenic networks, his research aims to understand the interaction between oncogenes and tumor suppressor genes. Specifically, his lab investigates the regulatory mechanisms underlying the crosstalk between aging and cancer, emphasizing the role of posttranslational modifications and ubiquitination in vital biological processes essential for cancer progression and metastasis. Dr. Lin also explores cancer stem cell regulation, cancer immunity, and drug resistance through various biochemical and molecular approaches, including genetic mouse models. His ultimate goal is to develop small molecule inhibitors and antibodies that target critical oncogenic signaling pathways and metabolic vulnerabilities for effective cancer treatment. His research interests encompass themes such as the biology of normal and cancer stem cells, metabolism in aging and cancer, and therapeutic strategies to overcome drug resistance in human cancers.
Department of Biomedical Engineering (MS program)