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Iain M. Cheeseman analyzes how cells duplicate, focusing on the molecular machinery that segregates chromosomes across diverse physiological contexts. His research is particularly fascinated by the proteins that direct chromosome segregation during cell division and the macromolecular kinetochore structure that mediates chromosome-microtubule interactions. Cell division is an essential cellular process, and its machinery showcases a remarkable flexibility in composition and properties that can vary dramatically across species and in response to developmental changes and diverse physiological situations. He aims to define the basis of the kinetochore as a core cellular structure, rewired to adapt to diverse functional requirements. Currently, his investigations encompass the transcriptional, translational, and post-translational mechanisms that generate proteomic variability among individual cells and tissues, informed by cell state, developmental stages, and disease contexts.
Massachusetts Institute of Technology • Cambridge, MA
Whitehead Institute • Cambridge, MA
Massachusetts Institute of Technology • Cambridge, MA