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Iva Tchasovnikarova is an accomplished researcher in the field of biochemistry, focusing on the genetic interrogation of epigenetic pathways. Her work emphasizes the importance of epigenetic modifications to DNA, RNA, and histones as key regulators of DNA-templated processes, including transcription, DNA repair, and replication. Disruptions in these epigenetic pathways are commonly observed in a variety of human conditions, such as developmental disorders and cancer. Due to the reversible nature of these disruptions, epigenetic regulators present attractive targets for therapeutic manipulation. Tchasovnikarova employs high-throughput genetic technologies and CRISPR/Cas9 forward genetic screens to uncover novel factors involved in chromatin regulation. Her lab strives to develop innovative genetic technologies to characterize human cell epigenetic pathways. Research objectives include studying the mechanisms underlying epigenetic pathways corrupted by disease-associated mutations in chromatin regulators and understanding how chromatin modifiers function under healthy conditions. This research aims to provide insights into the molecular details of altered mechanisms in human disorders.
University of Cambridge • Cambridge, ENG, GB
Leading research in epigenetic pathways and chromatin regulation.
Standard postgraduate requirements for Department of Politics and International Studies (POLIS) and related humanities departments.