Dr. J Ralphe

Biography

J. Carter Ralphe is a tenured professor and division chief of Pediatrics at the University of Wisconsin School of Medicine and Public Health. He is a pediatric cardiologist with expertise in both ambulatory and inpatient care, specializing in echocardiography. Dr. Ralphe has a keen interest in cardiomyopathy, particularly in inherited forms such as hypertrophic cardiomyopathy. His research aims to develop rational risk assessment tools to help children with genetic predispositions to hypertrophic cardiomyopathies live fulfilling lives. He employs a collaborative approach to ensure the highest quality of congenital heart care for his patients and their families. Dr. Ralphe's research specifically focuses on understanding mutations in genes linked to hypertrophic cardiomyopathy (HCM) and how these mutations alter cardiac cell function leading to hypertrophic remodeling. His team primarily studies cardiac myosin binding protein C (cMyBP-C), a contractile regulatory protein frequently implicated in HCM. Additionally, he directs a National Institutes of Health (NIH)-funded research laboratory that specializes in genetic forms of cardiomyopathy, providing a rich environment for pre- and post-doctoral trainees in basic and translational cardiac physiology.

Research Interests