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The Zippin Lab employs a wide range of biological systems to investigate skin biology using genetically engineered mouse models, mouse and human cell lines, and tumor organoids. The lab uses a variety of techniques, including biochemical, transcriptomic, proteomic, and mass spectrometry analyses, to unravel the role of non-canonical cAMP signaling pathways in melanocytes, keratinocytes, and T cells under normal and pathologic conditions. In some cases, the lab takes an interdisciplinary approach to understanding cAMP signals in skin to establish novel biomarkers of disease and therapeutic targets. The Zippin Lab is based in New York City within the Department of Dermatology at Weill Cornell Medical College and NewYork-Presbyterian Hospital and actively collaborates with the Department of Pharmacology, the Sandra and Edward Meyer Cancer Center, and the Englander Institute of Precision Medicine. The lab aims to understand the non-canonical cAMP signaling pathways and the distinct cAMP microdomains that function in normal skin biology and disease, developing novel cancer diagnostics and therapeutic targets through their innovative research efforts.
Zippin Lab, Weill Cornell Medicine • New York City, NY
Leading research on cAMP signaling pathways in skin biology and disease.
Department of Architecture