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Dr. Jacob S. Brenner is an Assistant Professor at the Department of Systems Pharmacology and Translational Therapeutics in the Perelman School of Medicine at the University of Pennsylvania. He is board certified and fellowship trained in critical care, attending the Medical Intensive Care Unit at the Hospital of the University of Pennsylvania. Alongside his clinical duties, he co-directs Penn's Center for Targeted Therapeutics & Translational Nanomedicine. Dr. Brenner's research expertise spans the development of novel gene therapies utilizing nanotechnology and nanomedicine. His laboratory focuses on producing safe and effective DNA-loaded lipid nanoparticles (DNA-LNPs) for treating various chronic diseases, including genetic disorders, pulmonary hypertension, obesity, and diabetes. He also works on engineered lipid nanoparticles (LNPs) to address acute critical illnesses like ischemic stroke and sepsis. Dr. Brenner is involved in identifying the toxicological aspects of his treatments and applying complexity science to understand disease dynamics better.
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