Dr. Jahangir Alam

Biography

Md Jahangir Alam is a Research Fellow at the Therapeutic Antibodies Inflammation Lab within the Biomedicine Discovery Institute (BDI) at Monash University. His research focuses on bridging the gap between academic and translational medicine by developing new therapeutic monoclonal antibodies (mAbs) for the treatment of autoimmune diseases, inflammatory disorders, and cancers. Specifically, he is involved in developing mAbs that target G-protein-coupled receptors (GPCRs) associated with these conditions, and he tests the therapeutic efficacy and potential of mAb therapies in preclinical models using human receptor knock-in (KI) mice. Md Jahangir Alam completed his PhD in Immunology at Monash University in August 2023, under the supervision of Professor Charles Mackay and Associate Professor Remy Robert. During his doctoral studies, he excelled in generating and characterizing human receptor KI mice to investigate the therapeutic efficacy of anti-human mAbs in treating inflammatory preclinical disease models. His PhD research also introduced a novel treatment strategy for addressing inflammation associated with autoimmune diseases, which combines mAb therapies that selectively target and eliminate disease-causing immune cells with specialized dietary interventions rich in short-chain fatty acids (SCFAs) that promote a healthy gut microbiome and boost anti-inflammatory regulatory T cells (Tregs), thereby inducing immune tolerance in preclinical models.

Research Interests