Dr. James Eberwine

Biography

James H. Eberwine is the Elmer Holmes Bobst Professor of Pharmacology at the Perelman School of Medicine, University of Pennsylvania. His research focuses on the molecular basis of neuronal adaptation, particularly the adaptive processes associated with tetanic potentiation and glucocorticoid-induced adaptations. He employs various molecular biology techniques and has pioneered methods for analyzing gene expression in individual cells. Eberwine's laboratory's efforts are directed toward understanding the molecular underpinnings of neuronal functioning, utilizing reductionist experimental approaches that include single-cell genetics, cDNA cloning, situ hybridization, and protein profiling. He has developed procedures for analyzing cellular functioning using single cells, including methods that assess mRNA and protein complements. His work has demonstrated the significance of localized mRNA translation in neuronal dendrites, particularly in response to synaptic stimulation. Eberwine is involved in generating molecular bioprocess fingerprints for different cell types across disease states, aiming to predictably alter cellular responses. He holds degrees in Biochemistry from Yale University and Columbia University, where he completed his Ph.D.

Research Interests